With the possibility Cam Newton (ribs) sits Week 1 for the Carolina Panthers at Tampa Bay Buccaneers, it is best that you sit Newton and find a 1pm game replacement. Maybe Ben Roethlisberger (vs Browns) or Ryan Tannehill (vs Patriots) is still available in your league. With a 4:25pm EST start time, you will have no option but to play Derek Anderson, Josh McCown or Eli Manning with QBs Peyton Manning, Andrew Luck, Matthew Stafford, Philip Rivers, Colin Kaepernick and Tony Romo the only QBs playing late afternoon games, Sunday Night Football and Monday Night Football. If you are lucky, Carson Palmer might still be available, and if he is, he should be added as a FA, before the players get locked up and placed on waivers!